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August 9, 2024VaccinesOpen Access

Intranasal Delivery of Quillaja brasiliensis Saponin-Based Nanoadjuvants Improve Humoral Immune Response of Influenza Vaccine in Aged Mice

Fernando L. Silveira Florencia García Gabriel Garcı́a José A. Chabalgoity Silvina Rossi Mariana Baz

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Abstract

Increasing the effectiveness of vaccines against respiratory viruses is particularly relevant for the elderly, since they are prone to develop serious infections due to comorbidities and the senescence of the immune system. The addition of saponin-based adjuvants is an interesting strategy to increase the effectiveness of vaccines. We have previously shown that ISCOM matrices from

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Silveira et al. (2024) studied this question.

synapsesocial.com/papers/68e5cdb1b6db643587563c57 https://doi.org/10.3390/vaccines12080902

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