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August 8, 2024Proceedings of the National Academy of SciencesOpen Access

R-loop functions in Brca1 -associated mammary tumorigenesis

Huai-Chin Chiang Leilei Qi Payal Mitra Yimeng Huang Yanfen Hu Rong Li

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Abstract

Deleterious accumulation of R-loops, a DNA-RNA hybrid structure, contributes to genome instability. They are associated with

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Cite This Study

Chiang et al. (2024) studied this question.

synapsesocial.com/papers/68e5cfeeb6db6435875660a1 https://doi.org/10.1073/pnas.2403600121

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1R-Loop Functions in<i>Brca1</i>-Associated Mammary Tumorigenesis2024
2Abstract 3019: Dissecting <i>in vivo</i> functions of R-Loops in <i>Brca1</i>-associated DNA replication stress and mammary tumorigenesis2024
3BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage RepairOriginal Research · 2015 · 479 citations
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