Figure 2 from The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors

Immune-related gene expression associates with the response to ICIs. A, Gene expression differences between the tumors responsive (right) and nonresponsive (left) to ICI treatment. Significantly different genes after FDR correction are colored and labeled. B and C, GSEA comparing responders vs. the nonresponders using the Hallmark gene set and TIMEx cell types. FDR < 0.1 was used as the cutoff. D, Mann–Whitney comparison of responders and nonresponders for signatures reaching the 0.05 FDR threshold.