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August 6, 2024Frontiers in PharmacologyOpen Access

Data mining and safety analysis of dual orexin receptor antagonists (DORAs): a real-world pharmacovigilance study based on the FAERS database

Manxue Jiang Hao Li Lingti Kong

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Abstract

Using the Food and Drug Administration Adverse Event Reporting System (FAERS) database, four signal detection methods were applied to mine adverse drug events (ADEs) related to use of dual orexin receptor antagonists (DORAs) to provide reference for safe clinical use.

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Jiang et al. (2024) studied this question.

synapsesocial.com/papers/68e5d358b6db643587569e3c https://doi.org/10.3389/fphar.2024.1436405

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Safety of Dual Orexin Receptor Antagonist Daridorexant: A Disproportionality Analysis of Publicly Available FAERS Data2024 · 10 citations
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3Association between dual orexin receptor antagonists (DORAs) and suicidality: reports to the United States Food and Drug Administration Adverse Event Reporting System (FAERS)2024 · 8 citations
4P.021 Nonclinical studies of abuse potential with dual orexin-receptor antagonists: concordance with real-world use2024
5Data Mining of the Public Version of the FDA Adverse Event Reporting SystemOriginal Research · 2013 · 1,058 citations

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