Alkaloids from Duguetia flagellaris Huber (Annonaceae)

Ten aporphine alkaloids were isolated from ethanol extract of leaves, thin branches, and stem bark of Duguetia flagellairis Huber (Annonaceae); they were identified by 1H and 13C NMR spectroscopic techniques; five were aporphine strictu sensu: nornuciferine (1), isopiline (2), O-melhylisopiline (3), calycinine (3), duguevanine (5), and five 7-hydroxyaporphines: pachypodanthine (6), oliveroline (7), oliveroline β-N-oxide (8), oliveridine (9), and dugueline (10). Alkaloids 2, 6, 7, and 8 are being cited lor the first lime in Duguetia genus. This study also includes a literature review ol the chemical constituents ol the genus Duguetia, predominantly aporphine alkaloids, a l isolated from plants that occur m South America.