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Preclinical study observes debated roles of eosinophils in experimental colitis models, highlighting unclear therapeutic value of eosinophil depletion in inflammatory bowel disease.
A role for eosinophils in intestinal inflammation and fibrosis in the context of inflammatory bowel disease has been suggested, yet the precise nature, whether causal or secondary remains debated. Hence, it remains unclear whether targeting eosinophils should be further explored as a treatment option in inflammatory bowel disease.
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Jacobs et al. (2024) studied this question.
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