Cannabinoid receptor 2 plays a key role in renal fibrosis through inhibiting lipid metabolism in renal tubular cells

Shan Zhou; Xian Ling; Ye Liang; Qijian Feng; Chao Xie; Jiemei Li; Qiyan Chen; Jinhua Miao; Mengyao Zhang; Zhiru Li; Weiwei Shen; Xiaolong Li; Qinyu Wu; Xiaoxu Wang; Fan Fan Hou; Youhua Liu; Yaozhong Kong; Lili Zhou

doi:10.1016/j.metabol.2024.155978

Ask about this paper

Answers are grounded in this paper and cite their sources.

Abstract

Renal fibrosis is a common feature in various chronic kidney diseases (CKD). Tubular cell damage is a main characterization which results from dysregulated fatty acid oxidation (FAO) and lipid accumulation. Cannabinoid Receptor 2 (CB2) contributes to renal fibrosis, however, its role in FAO dysregulation in tubular cells is not clarified. In this study, we found CB2 plays a detrimental role in lipid metabolism in tubular cells.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zhou et al. (2024) studied this question.

synapsesocial.com/papers/68e5d57fb6db64358756bacd https://doi.org/10.1016/j.metabol.2024.155978

View Full Paper

Ask AI

Bookmark

Share

Cannabinoid receptor 2 plays a key role in renal fibrosis through inhibiting lipid metabolism in renal tubular cells

Ask about this paper

Abstract

Discussion

Cite This Study

Cannabinoid receptor 2 plays a key role in renal fibrosis through inhibiting lipid metabolism in renal tubular cells

Ask about this paper

Abstract

Discussion

Cite This Study

Keep reading

Keep reading