Prostate cancer–induced endothelial-cell-to-osteoblast transition drives immunosuppression in the bone–tumor microenvironment through Wnt pathway–induced M2 macrophage polarization

Guoyu Yu; Paul G. Corn; Celia Sze Ling Mak; Xin Liang; Miao Zhang; Patricia Troncoso; Jian H. Song; Song-Chang Lin; Xingzhi Song; Jingjing Liu; Jianhua Zhang; Christopher J. Logothetis; Marites P. Melancon; Theocharis Panaretakis; Guocan Wang; Sue-Hwa Lin

doi:10.1073/pnas.2402903121

August 5, 2024Proceedings of the National Academy of SciencesOpen Access

Prostate cancer–induced endothelial-cell-to-osteoblast transition drives immunosuppression in the bone–tumor microenvironment through Wnt pathway–induced M2 macrophage polarization

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Key Points

Prostate tumors drive an endothelial-cell-to-osteoblast transition that induces local immunosuppression in the bone through Wnt pathway–mediated M2 macrophage polarization.
Elevated expression of a 32-gene macrophage signature in bone metastasis samples correlates with reduced overall survival in bone-metastatic castration-resistant prostate cancer.
Immunohistochemical profiling of bone metastases reveals CD206-positive macrophages, highlighting cellular mechanisms that may explain resistance to immune checkpoint therapy.

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Implication

Translational analysis reveals that endothelial-to-osteoblast transition promotes M2 macrophage polarization in bone-metastatic prostate cancer, highlighting barriers to immunotherapy.

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Yu et al. (2024) studied this question.

synapsesocial.com/papers/68e5d57fb6db64358756bafe https://doi.org/10.1073/pnas.2402903121

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Prostate cancer–induced endothelial-cell-to-osteoblast transition drives immunosuppression in the bone–tumor microenvironment through Wnt pathway–induced M2 macrophage polarization

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Prostate cancer–induced endothelial-cell-to-osteoblast transition drives immunosuppression in the bone–tumor microenvironment through Wnt pathway–induced M2 macrophage polarization

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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