A challenging case of drug-induced cholestatic liver injury: How to approach?

Abstract Background Drug-induced liver injury (DILI) of cholestatic pattern presents a significant burden to the health care system. It is one of the most challenging liver disorders faced by hepatologists. It can have several histological features of different prognoses. The diagnosis depends on the exclusion of other related differential diagnoses. However, there is insufficient data on effective therapeutic strategies for such disorders. Case presentation: A female patient presenting with jaundice and pruritis that was eventually diagnosed as DILI of cholestatic pattern after exclusion of various related D.D. Conclusion we aimed to summarize the issues related to pathophysiology, clinical approach and management of such a challenging liver disorder.