Figure 2 from Tumor-Intrinsic Activity of Chromobox 2 Remodels the Tumor Microenvironment in High-grade Serous Carcinoma

CBX2 regulates immune-related pathways in a tumor cell–intrinsic fashion. A, Carcinoma EcoTyper epithelial states (S1–6) compared with CBX2 expression (top panel) and cytokine–cytokine receptor interaction pathway. B, Correlation (x-axis, rho) of CBX2 mRNA expression in 303 HGSC tumors with imputed cell type. Adjusted P value shown on y-axis. Imputation pipeline (e.g., CIBERSORT and TIDE) utilized follows underscore in title of plot (details included in Supplementary Table S4). C, Scatter plot of CBX2 mRNA expression and macrophage M2_TIDE. D, Scatter plot of CBX2 mRNA expression and MDSC_TIDE. E, Scatter plot of CBX2 mRNA expression and Macrophage M0_CIBERSORT. F, Scatter plot of CBX2 mRNA expression and T cell CD4⁺ effector memory_XCELL. G, An annotated tissue microarray was used to perform mIHC evaluating CBX2 expression and immune cell types. Plot demonstrating the relationship between % stromal CD68⁺/pStat3⁺ and CBX2 H-score. Statistical tests, unpaired t test (C) and Pearson correlation (D–G).