Knee Varus as "Pre - Osteoarthritic Lesion" in Initiation and Progression of Knee Osteoarthritis in Perimenopausal Women

This study investigates the relationship between systemic bone mass, particularly osteoporosis, and knee varus deformity in perimenopausal women with knee pain. Through a comprehensive evaluation of clinical and radiological parameters, we found that osteoporosis significantly increases the risk of developing varus deformity, a condition linked to the progression of knee osteoarthritis. Our analysis revealed lower bone mineral density BMD in patients with varus deformity, particularly in the lumbar spine, femoral neck, and hip. The findings suggest that maintaining systemic bone mass may delay the progression of knee osteoarthritis, highlighting the need for early diagnosis and targeted interventions.