A low level of tumor necrosis factor α in tumor microenvironment maintains the self-renewal of glioma stem cells by Vasorin-mediated glycolysis

Yang Zhang; Tianxu Kang; Yuxi Wang; Chao Song; Huan Li; Hailong Mi; Yachao Li; Minhai Dong; Xiaoyu Ma; Hongtao Zhu; Lidong Cheng; Po Zhang; Zhiye Chen; Lin Zhou; Qiulian Wu; Feng Mao; Baofeng Wang; Suojun Zhang; Kai Shu; Feng Wan; Wenchao Zhou; Jeremy N. Rich; Jianying Shen; Qungen Xiao; Xingjiang Yu

doi:10.1093/neuonc/noae147

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Abstract

Self-renewal of glioma stem cells (GSCs) is responsible for glioblastoma (GBM) therapy resistance and recurrence. Tumor necrosis factor α (TNFα) and TNF signaling pathway display an antitumor activity in preclinical models and in tumor patients. However, TNFα exhibits no significance for glioma clinical prognosis based on the Glioma Genome Atlas database. This study aimed to explore whether TNFα of tumor microenvironment maintains self-renewal of GSCs and promotes worse prognosis in glioma patients.

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Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e5d9e3b6db64358756f97c https://doi.org/10.1093/neuonc/noae147

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A low level of tumor necrosis factor α in tumor microenvironment maintains the self-renewal of glioma stem cells by Vasorin-mediated glycolysis

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Abstract

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Cite This Study

A low level of tumor necrosis factor α in tumor microenvironment maintains the self-renewal of glioma stem cells by Vasorin-mediated glycolysis

Ask about this paper

Abstract

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Cite This Study

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