Vitamin B₁₂ as a source of variability in isotope effects for chloroform biotransformation by Dehalobacter

Elizabeth Phillips; Katherine J. Picott; Steffen Kümmel; Olivia Bulka; Elizabeth A. Edwards; Po‐Hsiang Wang; Matthias Gehre; Ivonne Nijenhuis; Barbara Sherwood Lollar

doi:10.1002/mbo3.1433

August 1, 2024MicrobiologyOpenOpen Access

Vitamin B₁₂ as a source of variability in isotope effects for chloroform biotransformation by Dehalobacter

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Key Points

Cobamide cofactor structure significantly alters carbon and chlorine isotope fractionation during reductive dechlorination of chloroform by microbial cultures.
Microcosm experiments examined two Dehalobacter subcultures expressing the reductive dehalogenase CfrA with exogenous cobamide additions like vitamin B12.
Highlights that enzyme cobamide composition drives isotopic variability, informing site remediation monitoring and groundwater assessment protocols.

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Implication

Microcosm study reveals cobamide variation alters carbon and chlorine isotope effects during chloroform biotransformation in Dehalobacter cultures, highlighting cofactor-driven isotopic fractionation.

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Phillips et al. (2024) studied this question.

synapsesocial.com/papers/68e5dc5db6db643587572426 https://doi.org/10.1002/mbo3.1433

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Vitamin B₁₂ as a source of variability in isotope effects for chloroform biotransformation by Dehalobacter

Key Points

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Discussion

Cite This Study

Vitamin B₁₂ as a source of variability in isotope effects for chloroform biotransformation by Dehalobacter

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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