In vitro analysis reveals metabolic features of HL-60 cell neutrophilic differentiation under hyperglycemia, highlighting impaired pathogen killing mechanisms.
Chronic hyperglycemia affects neutrophil functions, leading to reduced pathogen killing and increased morbidity. This impairment has been directly linked to increased glycemia, however, how this specifically affects neutrophils metabolism and their differentiation in the bone marrow is unclear and difficult to study.
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Cázares-Preciado et al. (2024) studied this question.
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