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Preclinical analysis reveals aggravated acid-induced acute lung injury under Cnot3 deficiency, indicating that the CCR4-NOT complex restrains severe inflammatory lung damage.
Acute lung injury (ALI) is caused by a variety of illnesses, including aspiration pneumonia and sepsis. The CCR4-NOT complex is a large multimeric protein complex that degrades mRNA through poly(A) tail shortening, whereas it also contributes to regulation of transcription and translation. Cnot3 is a scaffold component of the CCR4-NOT complex and is essential for the integrity of the complex; loss of Cnot3 leads to depletion of whole complex. While the significance of cytokine mRNA degradation in limiting inflammation has been established, the roles of CCR4-NOT complex-mediated in ALI remain elusive.
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Yamaguchi et al. (2024) studied this question.
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