Skin cancer: What happens in the laboratory?

BackgroundSkin cancer specimen handling in Australian histopathology laboratories, while largely standardised, exhibits significant variations that affect clinical decision-making and patient outcomes. ObjectiveThis article provides clinicians with an understanding of histopathological processes to enhance diagnostic precision, inform surgical margin evaluations and refine management approaches. DiscussionUnderstanding specimen handling and protocols is vital for accurate interpretation of pathology reports and management of skin cancers.Variations in sampling, examination and sectioning can affect pathological diagnosis and margin assessment.Clinician insights into laboratory processes are crucial for best practice.Retention of specimens and reports allows for further evaluation if clinical circumstances evolve or additional investigations are required.