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August 1, 2024Diabetes Metabolic Syndrome and ObesityOpen Access

Hepatocyte-Specific Yap1 Knockout Maintained the Liver Homeostasis of Lipid Metabolism in Mice

Caige Li Yu Xue Yiwei Liu Kangning Zheng Yuting Gao Yi Gong Junlan Lu Yuman Zhang Jingmin Ji Zhiqin Zhang Xinli Shi

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Abstract

Yes-associated protein 1 (YAP1) is a crucial molecule in the Hippo pathway. The impact of hepatocyte-specific

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Li et al. (2024) studied this question.

synapsesocial.com/papers/68e5dfdcb6db64358757465c https://doi.org/10.2147/dmso.s472778

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Hepatocyte-Specific Knockout of YAP Protects Against Atherosclerosis via Inhibition of ANGPTL3 in Micepreclinical · 2026
2Dynamic YAP expression in the non-parenchymal liver cell compartment controls heterologous cell communication2024 · 12 citations
3Targeting the Hippo- Yes-Associated Protein/Transcriptional Coactivator with PDZ-Binding Motif Signaling Pathway in Primary Liver Cancer Therapy2024 · 3 citations
4Targeting the Hippo-YAP/TAZ Signaling Pathway in Primary Liver Cancer Therapy2024 · 2 citations
5Consequences of Transient YAP Signaling in the Liver2024

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YAP1 in control: how RNA networks and protein modifications shape its function and therapeutic targetability2026
Hippo pathway-mediated YAP1/TAZ inhibition is essential for proper pancreatic endocrine specification and differentiation2024
Aging‐Dependent Hepatic <scp>YAP1</scp> Reduction Promotes Metabolic Dysfunction‐Associated Steatotic Liver Disease via Gut Microbiota Dysbiosis With <i>Akkermansia muciniphila</i> Downregulation2026

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