Longitudinal case series study in individuals with chromomycosis treated with azoles in the public health system of Brasília, Brazil

Chromomycosis is a chronic skin disease caused by fungi. This study aims to evaluate the use of itraconazole and voriconazole (azoles) in the treatment of chromomycosis. It is a descriptive longitudinal case series study conducted in Brasília, Brazil, between March 2007 and February 2020. Data were collected from 21 individuals diagnosed with chromomycosis treated with azoles, 18 men and 3 women. Data analysis was performed using IBM SPSS (Statistical Package for the Social Sciences) 21, 2015. The predominant etiological agent in the study was Fonsecaea pedrosoi(95.24%). The main clinical presentations of the disease in participants were erythematous plaque (52.38%) and verrucous form (38.10%). Of the individuals in the study, 19.05% showed no improvement, 61.9% achieved improvement, and 19.05% achieved clinical and laboratory cure. Therefore, azoles demonstrated high efficacy and safety in the treatment of chromomycosis. Itraconazole proved to be a good choice, while voriconazole showed superior results. The findings indicate promising prospects for the treatment of chromomycosis.