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August 1, 2024Neuro-Oncology AdvancesOpen Access

BSLM-06 Prognostic Significance of Cerebrospinal Fluid Glucose and Protein Levels in Metastatic Breast Cancer Patients With Leptomeningeal Disease: A Retrospective Study

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Authors

SNSujan NiraulaSGSugam GauliABAndrea Baran

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Overview

Retrospective study shows that low cerebrospinal fluid glucose correlates with worse overall survival in metastatic breast cancer with leptomeningeal disease, highlighting its value as a biomarker.

Key Points

  • Low cerebrospinal fluid glucose levels correlate with significantly reduced overall survival in metastatic breast cancer patients diagnosed with leptomeningeal disease.
  • A hazard ratio of 4.64 linked low glucose levels to worse survival, whereas cerebrospinal fluid protein showed no prognostic association in multivariate analysis.
  • Retrospective study across 28 patients indicates that cerebrospinal fluid glucose serves as a valuable prognostic marker, though larger external validation cohorts are needed.

Cite This Study

Niraula et al. (2024) studied this question.

synapsesocial.com/papers/68e5e1ceb6db643587575d12https://doi.org/10.1093/noajnl/vdae090.017
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