Investigation of the Predictive Value of De Ritis Ratio and Inflammatory Markers in Prostate Cancer Patients Suitable for Active Surveillance

Objective: To demonstrate the role of inflammatory markers and the De Ritis ratio (aspartate aminotransferase/alanine aminotransferase) in selecting patients with localized prostate cancer for active surveillance.Methods: A total of 83 patients who met the criteria for active surveillance and underwent radical prostatectomy in our clinic between January 2010 and June 2017 were included in the study.Preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet-tohemoglobin (Plt/Hb) ratio, red cell distribution width (RDW), and De Ritis ratio were retrospectively evaluated with postoperative outcomes.Results: NLR, PLR, RDW, and Plt/Hb ratios were not significantly associated with upgrade and upstage.Twenty-three patients (27.7%) underwent upgrade, 10 patients (12%) underwent upstage, and 29 patients (34.9%) were found unsuitable for active surveillance of radical prostatectomy results.A high De Ritis ratio was significantly associated with increased upgrade and unsuitability for active surveillance. Conclusion:Preoperatively, a high De Ritis ratio is associated with poor pathological outcomes, and a high De Ritis ratio can be used as a costeffective and accessible marker for selecting patients for active surveillance.