Investigation of extract from jasminum subtriplinerve blume leaves for acute and subchronic oral toxicity in experimental animals

This research is conducted to evaluate the acute and subchronic toxicities of the extract of Jasminum subtriplinvere Blume leaves through oral administration in experimental animals. The acute toxicity was determined by the Litchfield Wilcoxon method in Swiss mice. The subchronic toxicity was evaluated by WHO and OECD’s recommendation in Wistar rats with oral doses of 2.4 g/kg/day and 7.2 g/kg/day for 90 consecutive days. We found no sign of toxicity and no mortality was observed in Jasminum subtriplinvere Blume treated mice at 5000 mg/kg. In terms of the subchronic toxicity test, after oral administration of the extract of Jasminum subtriplinvere Blume, hematological parameters, hepato-renal functions, and microscopic images of the liver and kidney were unchanged as compared with the control group. In conclusion, the extract of Jasminum subtriplinvere Blume leaves did not produce acute and subchronic toxicities in Swiss mice and Wistar rats.