Mucosal Single-Cell Profiling of Crohn’s-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets

Siyan Cao; Khai Nguyen; Kaiming Ma; Xiaotang Du; Xiuli Liu; Alina Ulezko Antonova; Richard P. Rood; Anas Gremida; Chien-Huan Chen; Alexandra Gutierrez; Deborah C. Rubin; Martin Gregory; M Gergely; Guadalupe Oliva Escudero; Katherine Huang; Natália Jaeger; Marina Cella; Rodney D. Newberry; Nicholas O. Davidson; Matthew A. Ciorba; Parakkal Deepak; Marco Colonna

doi:10.1053/j.gastro.2024.07.025

Abstract

The pathophysiology of Crohn's-like disease of the pouch (CDP) in patients with a history of ulcerative colitis (UC) is unknown. We examined mucosal cells from patients with and without CDP using single-cell analyses.

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Cao et al. (2024) studied this question.

synapsesocial.com/papers/68e5e6efb6db64358757b976 https://doi.org/10.1053/j.gastro.2024.07.025

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Mucosal Single-Cell Profiling of Crohn’s-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets

Abstract

Discussion

Cite This Study

Mucosal Single-Cell Profiling of Crohn’s-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets

Abstract

Discussion

Cite This Study

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