Genomic analysis reveals dominance of the M1UK lineage in invasive disease patients, suggesting pediatric pharyngitis prevention could curb severe infections.
M1UK is associated with current surges in invasive infection globally, partly due to increased production of superantigen streptococcal pyrogenic exotoxin A. We show that M1UK is now the dominant invasive emm1 lineage in Aotearoa New Zealand and is genomically related to community infections, suggesting that measures that effectively prevent group A Streptococcus pharyngitis in children could reduce invasive disease.
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Vesty et al. (2024) studied this question.
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