CDK5RAP3 Inhibition by Hypoxia Activates P38MAPK to Facilitate Angiogenesis

Mengmeng Zhang; Yang Liu; Jun Shu; Xin Gu; Han Yan

doi:10.1536/ihj.23-604

July 30, 2024International Heart JournalOpen Access

CDK5RAP3 Inhibition by Hypoxia Activates P38MAPK to Facilitate Angiogenesis

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Key Points

Hypoxic inhibition of tumor suppressor CDK5RAP3 facilitates angiogenesis in human umbilical vein endothelial cells by triggering p38MAPK activation.
Assessment under 2% oxygen shows CDK5RAP3 levels decline over time in vascular endothelial growth factor-induced human umbilical vein endothelial cells.
Uncovering this hypoxic CDK5RAP3 and p38MAPK signaling cascade highlights angiogenic mechanisms; in vitro cell culture model requires preclinical validation.

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Implication

In vitro study shows CDK5RAP3 reduction activates p38MAPK under hypoxia in human umbilical vein endothelial cells, suggesting a pathway driving angiogenesis.

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Cite This Study

Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e5e6ffb6db64358757c289 https://doi.org/10.1536/ihj.23-604

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CDK5RAP3 Inhibition by Hypoxia Activates P38MAPK to Facilitate Angiogenesis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

CDK5RAP3 Inhibition by Hypoxia Activates P38MAPK to Facilitate Angiogenesis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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