Lacticaseibacillus rhamnosus HA-114 and Bacillus subtilis R0179 Prolong Lifespan and Mitigate Amyloid-β Toxicity in C. elegans via Distinct Mechanisms

Stuart G. Foster; Shibi Mathew; Audrey Labarre; J. Alex Parker; Thomas A. Tompkins; Sylvie Binda

doi:10.3233/jad-230948

July 30, 2024Journal of Alzheimer s DiseaseOpen Access

Lacticaseibacillus rhamnosus HA-114 and Bacillus subtilis R0179 Prolong Lifespan and Mitigate Amyloid-β Toxicity in C. elegans via Distinct Mechanisms

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Key Points

Lifespan extension and reduced amyloid beta toxicity occur following administration of Lacticaseibacillus rhamnosus and Bacillus subtilis through distinct pathways.
Assessment in Caenorhabditis elegans examines two bacterial strains to determine their individual impacts on survival rates and gut dysbiosis markers.
Highlights targeting the microbiota gut brain axis for Alzheimers disease management, though findings are limited to a C. elegans model requiring further validation.

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Implication

Preclinical study demonstrates extended lifespan and reduced amyloid-β toxicity in C. elegans, suggesting therapeutic potential for Alzheimer's disease.

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Foster et al. (2024) studied this question.

synapsesocial.com/papers/68e5e7feb6db64358757c444 https://doi.org/10.3233/jad-230948

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Lacticaseibacillus rhamnosus HA-114 and Bacillus subtilis R0179 Prolong Lifespan and Mitigate Amyloid-β Toxicity in C. elegans via Distinct Mechanisms

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Lacticaseibacillus rhamnosus HA-114 and Bacillus subtilis R0179 Prolong Lifespan and Mitigate Amyloid-β Toxicity in C. elegans via Distinct Mechanisms

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