Osteoarthritis (OA) is a common and debilitating joint illness characterized by cartilage deterioration, which causespain, stiffness, and decreased joint function. This review examines the pathophysiology of osteoarthritis and assessesthe efficacy of hyaluronic acid (HA) and glucosamine in treating the condition. Natural amino sugar glucosamine iswell-known for its ability to heal cartilage and for its anti-inflammatory properties. Hyaluronic acid (HA), an essential part of synovial fluid, lubricates joints and lowers friction. We examine clinical data supporting these substances' effectiveness, including how they affect joint function, pain management, and the course of disease. The reviewaddresses the mechanisms of action, efficacy, and limitations of both glucosamine and HA, as well as the synergisticpotential of combining the two. In addition, research initiatives for the future are delineated to augment comprehension and utilization of these therapies. The purpose of this review is to offer a thorough summary of thestate of the field and to direct future research efforts aimed at OA management optimization.
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Varagani et al. (2024) studied this question.
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