6334 Amplitude-integrated electroencephalography patterns in neonates with moderate birth asphyxia

Objectives Birth asphyxia is one of major causes of neonatal mortality worldwide.1 Amplitude – integrated electroencephalography is a useful tool for detecting electrical seizures and other abnormal electrical activities of the brain.2 This research was aimed to study association between amplitude-integrated electroencephalography patterns in neonates with moderate birth asphyxia and short term outcomes namely death or discharge with neurological deficits. Methods A one-year cross-sectional descriptive study was performed in Neonatal Intensive Care Unit of a tertiary paediatric hospital. Neonates with gestational age between 37 to Results Out of 28 neonates, 54% were female and 46% were male. Eighty-nine percent had weight ≥2.5kg. The commonest places of delivery were private hospitals (47%), followed by public hospitals (21%), health care centers (18%) and home deliveries (14%). Forty-six percent were born vaginally, 46% were born by Caesarean section and 8% were born by vacuum extraction. Mean age at the time of initiation of amplitude-integrated electroencephalography was 33 hours. Moderately abnormal amplitude-integrated electroencephalography patterns were found in 53%, severely abnormal patterns in 43% and normal patterns in only 4%. Electrical seizures were observed in 32% of neonates. All of those with electrical seizures showed clinical seizures during the course of hospital stay although not all clinical seizures were temporally related to electrical seizures. Forty percent of neonates with moderately abnormal amplitude-integrated electroencephalography patterns and 92% of neonates with severely abnormal patterns had poor short term outcomes namely death or discharge with neurological deficits. One neonate with normal amplitude-integrated electroencephalography patterns was discharged without short term neurological sequele. Seven neonates (58%) with severely abnormal amplitude-integrated electroencephalography patterns and 3 neonates (20%) with moderately abnormal patterns died. Conclusion A significant association was found between amplitude-integrated electroencephalography patterns and short term outcomes in neonates with moderate birth asphyxia (p=0.008). References Doandes, FM, Manea, A-M, Lungu, N, Cioboata, D, et al. Clinical, biological and electroencephalographic monitoring of newborns with neurological risk in the neonatal intensive care unit. Experimental and Therapeutic Medicine 2021;22(1):760. Goyal, H, Sharma, G 04(04):591–594.