Variant Philadelphia Chromosome in Nine Cases of Chronic Myeloid Leukemia: Experience of a Tertiary Care Hospital in Eastern India

smear examination.Bone marrow (BM) aspiration was performed for cytogenetic study. Cytogenetic StudyAn unstimulated 24-hour culture of BM samples was subjected to conventional cytogenetic analysis.Standard methods were used to culture and process the cells, and Giemsa-trypsin-Giemsa (GTG) banding was used to stain the chromosomes.The karyotype was characterized following the International System for Human Cytogenetic Nomenclature. 5,6 ResultsAmong the total 75 study participants, nine patients (12%) had variant Ph chromosome.The group of nine patients (12%) included one female and eight males, their age at diagnosis ranging from 37 to 70 years.At presentation, eight patients were in the chronic phase, and one was experiencing a blast crisis.Five of these patients (cases 1, 2, 5, 7, and 8) presented de novo, while the remaining patients (cases 3, 4, 6, and 9) presented with disease progression while on therapy and were treated as per