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July 29, 2024Frontiers in ImmunologyOpen Access

Fluvoxamine maleate alleviates amyloid-beta load and neuroinflammation in 5XFAD mice to ameliorate Alzheimer disease pathology

Sukhleen Kaur Kuhu Sharma Ankita Sharma Kamalpreet Kaur Sandha Syed Mudassir Ali Riyaz Ahmed P. Ramajayan Parvinder Pal Singh Zabeer Ahmed Ajay Kumar

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Abstract

Alzheimer pathology (AD) is characterized by the deposition of amyloid beta (Aβ) and chronic neuroinflammation, with the NLRP3 inflammasome playing a significant role. This study demonstrated that the OCD drug fluvoxamine maleate (FXN) can potently ameliorate AD pathology in 5XFAD mice by promoting autophagy-mediated clearance of Aβ and inhibiting the NLRP3 inflammasome.

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Cite This Study

Kaur et al. (2024) studied this question.

synapsesocial.com/papers/68e5ea28b6db64358757e812 https://doi.org/10.3389/fimmu.2024.1418422

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