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July 29, 2024Open Access

Supplementary Figure 3 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

Yusuke Goto Keiichi Koshizuka Toshinori Ando Hiroki Izumi Xingyu Wu Kuniaki Sato Tomohiko Ishikawa Kyle Ford Xiaodong Feng Zhiyong Wang Nadia Arang Michael M. Allevato Ayush Kishore Prashant Mali J. Silvio Gutkind

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Abstract

Upregulation of CCNE1 by palbociclib confers resistance to palbociclib, which can be reverted by INK128

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Cite This Study

Goto et al. (2024) studied this question.

synapsesocial.com/papers/68e5eb3bb6db643587580397 https://doi.org/10.1158/2767-9764.26392690

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 3 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC2024
2Supplementary Figure 3 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC2024
3Supplementary Figure 2 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC2024
4Supplementary Figure 2 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC2024
5Supplementary Figure 2 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC2024