Investigating the possible effects of AKT and FAK signaling pathways' inactivation on TNBC cell proliferation and TNBC patients' recurrence free survival via BAG3 regulation

Currently, a lethal breast cancer called TNBC (triple-negative breast cancer) has been researched for decades. Related research has shown the mechanism of this cancer and the ways to recover it. According to the research, two signal pathways called AKT and FAK, existing downstream of BAG 3 (BCL2- associated athanogene3), were found as two triggers to positively regulate BAG 3 thus causing TBNC cell proliferation. Therefore, the question is: what is the effect of BAG 3 when AKT and FAK are inactivated? Will BAG 3 still be transcribed to cause TNBC cell proliferation? This paper lists all possible results of TNBC numbers (in petri dish) and tumor volumes (in mice as xenograft) changing by inactivating AKT and FAK, respectively, inactivating both or not inactivating, and lists possible reasons that cause these results.