Optimizing detection and prediction of cognitive function in multiple sclerosis with ambulatory cognitive tests: Protocol for the longitudinal observational “CogDetect-MS” study (Preprint)

Cognitive dysfunction is a common problem in multiple sclerosis (MS). Progress toward understanding and treating cognitive dysfunction is thwarted by the limitations of traditional cognitive tests, which demonstrate poor sensitivity and ecological validity. Ambulatory methods of assessing cognitive function in the lived environment may improve the detection of subtle changes in cognitive function and the identification of predictors of cognitive changes and downstream effects of cognitive change on other functional domains.