The CRISPR (Cluster of regularly interspersed short palindromic repeats) technology is the nowadays trend of genetic engineering. The simplicity of the system has made genetic engineering more applicable and convenient for bioengineers, in comparison to ZFNs and TALENs. It is now used in a wide range of aspect, by inserting, deleting, silencing, mutating the target gene. However, this technology still has drawbacks. Off-target affect, one of the most common shortcoming has made this technology often considered to be too risky to be put in actual treatment. CRISPR technology holds a great promising prospect in cancer treatment and immunotherapy through enhancing the direct or indirect inhibition of cancer growth. This article will provide an overview of the CRISPR system, its application in studying and screening of cancer cells, improving the efficacy and specificity of cancer immunotherapy, and possible future direction of cancer treatment, for example editing or modifying oncogene and drug resistant genes.
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Junxin Zhang (2024) studied this question.
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