Effect of Agitation Speed: Three Different Dissolution Methods on in-vitro Release of Plain Disulfiram Implant

Disulfiram has been the first choice of drug for the physician to treat alcoholism. The oral effect of disulfiram is limited because of less patient compliance and poor bioavailability. Attempts were made to develop subcutaneously implantable disulfiram pellet or tablet dosage forms to reduce oral medication failure. The present study attempts to prepare and evaluate an implant of disulfiram by using a direct compression method. The effect of agitation speed with three different in vitro dissolution methods i.e., Vial Method (VM) (5min Shaking at sampling time), Rotary Flask Shaker Method (RFM) (25 RPM), and Intrinsic Dissolution Method (IDM) (50 RPM) were studied for in-vitro release of disulfiram implant. The results showed the steady release rate of formulation (S3, S7, S11, and S15) at varying compression forces obtained by three methods (VM, RFM and IDM) are different significantly with p value <0.0001. Thus, the effect of agitation speed with three different methods (VM, RFM and IDM) had a distinct effect of plain disulfiram Implant on in-vitro release. All the formulations were subjected to different dissolution kinetic treatment models (Zero order, First order, Higuchi Square root, and Korsmeyer Peppas), upon studying the release and release kinetics, the release kinetic mechanism was found to be zero order from all formulations.