Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer’s Disease

Eric McDade; Haiyan Liu; Quoc Bui; Jason Hassenstab; Brian A. Gordon; Tammie L.S. Benzinger; Yuanyuan Shen; Jigyasha Timsina; Lihua Wang; Yun Ju Sung; Celeste M. Karch; Alan E. Renton; Alisha Daniels; John Morris; Chengjie Xiong; Laura Ibáñez; Richard J. Perrin; Jorge J. Llibre‐Guerra; Gregory S. Day; Charlene Supnet; Xu Xiong; Sarah Berman; Jasmeer P. Chhatwal; Takeshi Ikeuchi; Kensaku Kasuga; Yoshiki Niimi; Edward D. Huey; Peter R. Schofield; William S. Brooks; Natalie S. Ryan; Mathias Jucker; Christoph Laske; Johannes Levin; Jonathan Vöglein; Jee Hoon Roh; Francisco Lopera; Randall J. Bateman; Carlos Cruchaga

doi:10.21203/rs.3.rs-4202125/v1

Abstract

This study explored the role of the ubiquitin-proteasome system (UPS) in dominantly inherited Alzheimer's disease (DIAD) by examining changes in cerebrospinal fluid (CSF) levels of UPS proteins along with disease progression, AD imaging biomarkers (PiB PET, tau PET), neurodegeneration imaging measures (MRI, FDG PET), and Clinical Dementia Rating

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McDade et al. (2024) studied this question.

synapsesocial.com/papers/68e5f50bb6db643587589aa5 https://doi.org/10.21203/rs.3.rs-4202125/v1

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Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer’s Disease

Abstract

Discussion

Cite This Study

Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer’s Disease

Abstract

Discussion

Cite This Study

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