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July 23, 2024Future Medicinal Chemistry

Synthesis of indole-functionalized isoniazid conjugates with potent antimycobacterial and antioxidant efficacy

Renu Gavadia Jyoti Rasgania N.P. Sahu Mandira Varma‐Basil Varsha Chauhan Sanjay Kumar Satbir Mor Devender Singh Komal Jakhar

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Abstract

Developing potent medicinal alternates for tuberculosis (TB) is highly desirable due to the advent of drug-resistant lethal TB strains.

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Gavadia et al. (2024) studied this question.

synapsesocial.com/papers/68e5f61cb6db64358758a0f6 https://doi.org/10.1080/17568919.2024.2379240

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Design and Synthesis of Isatin‐Tagged Isoniazid Conjugates with Cogent Antituberculosis and Radical Quenching Competence: <i>In‐vitro</i> and <i>In‐silico</i> Evaluations2024 · 1 citations
2Structural features, activity relationships, and synthetic strategies of indole-based derivatives as antitubercular agents targeting mycolic acid biosynthesisReview · 2026
3Exploring Indole-Linked Triazole Sulfonamide Derivatives as Potent Mycobacterial Carbonic Anhydrase Inhibitors: Leveraging a Tail Approach for the Design, Synthesis, and <i>In Silico</i> Studies─An In-Depth Multidisciplinary Study2025 · 11 citations
4Synthesis and InhA Inhibition of Imidazo[1,2-a]pyridine Derivatives as Anti-Tuberculosis Agents2024 · 1 citations
5Exploration of Pyridine‐4‐hydrazide Derivatives as Promising Antitubercular Agents: Synthesis, Biological Evaluation, and In Silico Studies2025 · 6 citations

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The Potential of Isoniazid Derivatives as Anti-Tuberculosis Drugs targeting 6MA8: In Silico Study2025
Exploration of New Dihydroindazole Derivatives as Promising Anti‐TB Agents: Design, Synthesis, In Silico, and Biological Evaluation2025
Synthesis, Antitubercular Activity, and Computational Characterization of Novel Phenylpyrazole‐Isoniazid Derivatives2026

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