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July 22, 2024PharmaceuticalsOpen Access

A First Metabolite Analysis of Norfolk Island Pine Resin and Its Hepatoprotective Potential to Alleviate Methotrexate (MTX)-Induced Hepatic Injury

Sherouk Hussein Sweilam Dalia E. Ali Ahmed M. Atwa Ali M. Elgindy Aya M. Mustafa Manar M. Esmail Mahmoud Abdelrahman Alkabbani Mohamed Magdy Senna Riham A. El‐Shiekh

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Abstract

Drug-induced liver injury (DILI) represents a significant clinical challenge characterized by hepatic dysfunction following exposure to diverse medications. Methotrexate (MTX) is a cornerstone in treating various cancers and autoimmune disorders. However, the clinical utility of MTX is overshadowed by its ability to induce hepatotoxicity. The current study aims to elucidate the hepatoprotective effect of the alcoholic extract of Egyptian

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Sweilam et al. (2024) studied this question.

synapsesocial.com/papers/68e5f733b6db64358758b9f0 https://doi.org/10.3390/ph17070970

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Pharmacological Mechanisms of Phytochemicals and Pharmaceutical Agents in Protecting Against Methotrexate‐Induced Liver InjuryClinical Trial · 2026 · 1 citations
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