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July 22, 2024Journal of Ginseng ResearchOpen Access

20(S)-Ginsenoside Rh2 induces apoptosis and autophagy in melanoma cells via suppressing Src/STAT3 signaling

Jun‐Kui Li Xiaoli Jiang Zhu Zhang Wenqing Chen Junjie Peng Bin Liu Ken‐Kin‐Lam Yung Peili Zhu

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Abstract

20(S)-Ginsenoside Rh2 (GRh2) has been extensively studied for multifaceted health benefits. However, the anti-melanoma effect of GRh2 remains poorly understood. Herein, the anti-melanoma effects and underlying mechanisms of GRh2 were investigated.

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Li et al. (2024) studied this question.

synapsesocial.com/papers/68e5f733b6db64358758ba71 https://doi.org/10.1016/j.jgr.2024.07.002

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Ginsenoside Rh2 inhibits proliferation and induces apoptosis in human leukemia cells via TNF-&alpha; signaling pathwaypreclinical · 2016 · 39 citations
2Ginsenoside Rh2 Regulates the Calcium/ROS/CK1α/MLKL Pathway to Promote Premature Eryptosis and Hemolysis in Red Blood Cells2024 · 2 citations
320(s)-ginsenoside Rh2 promotes TRAIL-induced apoptosis by upregulating DR5 in human hepatocellular carcinoma cellspreclinical · 2021 · 1 citations
4Ginsenoside Rg3 inhibits melanoma progression by inducing ferroptosis via the p53/SLC7A11/GPX4 pathwayOriginal Research · 2025 · 8 citations
520(S)-Ginsenoside Rh2 inhibits hepatocellular carcinoma by suppressing angiogenesis and the GPC3‐mediated Wnt/&beta;‑catenin signaling pathway2024 · 12 citations

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