Orange mistletoe (Scurrula ferruginea (Roxb. ex Jack) Danser) is a common mistletoe found in Indonesia and often used as a herbal drink. This mistletoe has active compound such as terpenoids, tannins, saponins and flavonoids acts as antimicrobial and antioxidant. This research was conducted at the Microbiology Research Laboratory, Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Andalas. The method used in this research was experiment method with CRD nested pattern with 3 repetitions. The aims of this study were to clarifying the antimicrobial potency of orange mistletoe extract, to determining the MIC and MLC of the orange mistletoe extract, and to determining the antioxidant activity of orange mistletoe extract. The results showed that the greatest antimicrobial potency was found in the fresh extract of orange mistletoe which significantly different against Staphylococcus aureus (14.05 mm), Escherichia coli (10.57 mm) and Candida albicans (7.00 mm). The MIC of fresh extract against S. aureus was 12.5%, E. coli was 25%, and no MIC values against C. albicans, then no MLC values were found. The highest antioxidant activity value of Scurrula ferruginea was found in the fresh extract (118.22 µg/mL).
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