Observational study demonstrates sex- and age-dependent cardiovascular changes in offspring exposed to maternal perinatal stress, suggesting potential long-term multigenerational impact.
We demonstrate that maternal perinatal stress is associated with sex- and age-dependent impact on the cardiovascular system in their offspring. The effect was most significant in adolescent female and adult male offspring. Observed changes in hemodynamic parameters and dopaminergic activity of the medulla oblongata are novel results relevant to understanding the cardiovascular impact of maternal perinatal stress on the offspring. The cardiovascular changes observed in adult offspring suggest a potential long-term, multigenerational impact of maternal perinatal stress.
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Czarzasta et al. (2024) studied this question.
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