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July 17, 2024Journal of Agricultural and Food Chemistry

Engineering of Methionine Adenosyltransferase toward Mitigated Product Inhibition for Efficient Production of S-Adenosylmethionine

Qiangqiang Wang Weibin Lin Ye Ni Jinghui Zhou Gang Xu Ruizhi Han

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Abstract

-Adenosylmethionine (SAM) is a crucial metabolic intermediate playing irreplaceable roles in organismal activities. However, the synthesis of SAM by methionine adenosyltransferase (MAT) is hindered by low conversion due to severe product inhibition. Herein structure-guided semirational engineering was conducted on MAT from

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Wang et al. (2024) studied this question.

synapsesocial.com/papers/68e5fefbb6db6435875931bf https://doi.org/10.1021/acs.jafc.4c03715

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Efficient Enzymatic Synthesis and Cofactor Regeneration of Biomimetic <i>S</i> -Adenosyl- <scp>l</scp> -methionine for Enzymatic MethylationOriginal Research · 2026
2Enhanced synthesis of S-adenosyl-L-methionine through Combinatorial metabolic engineering and Bayesian optimization in Saccharomyces cerevisiae2024
3Journey of Methionine Adenosyltransferase 2A Inhibitors: From Bench to Advanced Clinical TrialsHuman Clinical Trial · 2026 · 2 citations
4Enhanced synthesis of S‐adenosyl‐L‐methionine through combinatorial metabolic engineering and Bayesian optimization in <i>Saccharomyces cerevisiae</i>2024 · 21 citations
5Efficient Transferase Engineering for SAM Analog Synthesis from Iodoalkanes2024 · 25 citations

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