July 17, 2024BMC Medical Research MethodologyOpen Access

Addressing researcher degrees of freedom through minP adjustment

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Authors

MMMaximilian M. MandlZimmer Biomet (Netherlands)ABAndrea Becker-PennrichZimmer Biomet (Netherlands)LHLudwig Christian HinskeUniversity of Augsburg

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Implication

Methodological evaluation demonstrates controlled family-wise error across 48 analysis strategies in neurosurgery, highlighting robust preservation of statistical power.

Key Points

Across 48 neurosurgery strategies, minP adjustment effectively controls the family-wise error rate, preserving power while correcting for researcher degrees of freedom.
Permutation-based procedure approximates the null distribution of minimal p-values across dependent tests, preventing statistical power loss from naive Bonferroni correction.
Highlights that selective reporting of optimal outcomes remains robust under multiple testing adjustments, minimizing the risk of publishing irreproducible false positive findings.

Cite This Study

Mandl et al. (2024) studied this question.

synapsesocial.com/papers/68e60123b6db643587594374 https://doi.org/10.1186/s12874-024-02279-2

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Implication

Methodological evaluation demonstrates controlled family-wise error across 48 analysis strategies in neurosurgery, highlighting robust preservation of statistical power.

Addressing researcher degrees of freedom through minP adjustment

Discussion

Member takes

Implication

Key Points

Cite This Study

Addressing researcher degrees of freedom through minP adjustment

Discussion

Member takes

Implication

Key Points

Cite This Study

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