Placebo-controlled split-face study demonstrates promising effects of topical metformin in melasma, highlighting an accessible treatment that may improve patient quality of life.
Melasma is a common condition that affects a patient's quality of life. Metformin is a cheap, well-tolerated and relatively safe medication that is widely prescribed for the treatment of diabetes. Topical metformin has shown promising results in treating melasma as well as several other dermatological conditions such as acne and recalcitrant central centrifugal cicatricial alopecia.
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El-Komy et al. (2024) studied this question.
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