UBXN3B is crucial for B lymphopoiesis

Tingting Geng; Duomeng Yang; Tao Lin; Andrew G. Harrison; Binsheng Wang; Ziming Cao; Blake L. Torrance; Zhichao Fan; Kepeng Wang; Yanlin Wang; Long Yang; Laura Haynes; Gong Cheng; Anthony T. Vella; Richard A. Flavell; João P. Pereira; Erol Fikrig; Penghua Wang

doi:10.1016/j.ebiom.2024.105248

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The ubiquitin regulatory X (UBX) domain-containing proteins (UBXNs) are putative adaptors for ubiquitin ligases and valosin-containing protein; however, their in vivo physiological functions remain poorly characterised. We recently showed that UBXN3B is essential for activating innate immunity to DNA viruses and controlling DNA/RNA virus infection. Herein, we investigate its role in adaptive immunity.

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Geng et al. (2024) studied this question.

synapsesocial.com/papers/68e60235b6db6435875956ca https://doi.org/10.1016/j.ebiom.2024.105248

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UBXN3B is crucial for B lymphopoiesis

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UBXN3B is crucial for B lymphopoiesis

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