Key result
Abstract omits results linking mosaic loss of Y chromosome to cardiovascular outcomes in CKD.
Why the study?
Chronic kidney disease is a strong risk factor for cardiovascular diseases and heart failure, but the association of mosaic loss of Y chromosome with mortality and cardiovascular outcomes in these patients is unclear.
Does mosaic loss of Y chromosome (LOY) associate with mortality and cardiovascular disease outcomes in patients with chronic kidney disease?
Observational
Does mosaic loss of Y chromosome (LOY) associate with mortality and cardiovascular disease outcomes in patients with chronic kidney disease?
Chronic kidney disease represents one of the strongest risk factors for cardiovascular diseases, and particularly for heart failure. Despite improved pharmaceutical treatments, mortality remains high. Recently, experimental studies demonstrated that mosaic loss of Y chromosome (LOY) associates with cardiac fibrosis in male mice. Since diffuse cardiac fibrosis is the common denominator for progression of all forms of heart failure, we determined the association of LOY on mortality and cardiovascular disease outcomes in patients with chronic kidney disease.
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Weyrich et al. (2024) conducted an observational in Chronic kidney disease. Mosaic loss of Y chromosome (LOY) was evaluated on Mortality and cardiovascular disease outcomes.
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