Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts

Yoshitaka Taketomi; Takayoshi Higashi; Kuniyuki Kano; Yoshimi Miki; Chika Mochizuki; Shota Toyoshima; Yoshimichi Okayama; Yasumasa Nishito; Susumu Nakae; Satoshi Tanaka; Suzumi M. Tokuoka; Yoshiya Oda; Shigeyuki Shichino; Satoshi Ueha; Kouji Matsushima; Noriyuki Akahoshi; Satoshi Ishii; Jerold Chun; Junken Aoki; Makoto Murakami

doi:10.1016/j.immuni.2024.06.012

Abstract

Interaction of mast cells (MCs) with fibroblasts is essential for MC maturation within tissue microenvironments, although the underlying mechanism is incompletely understood. Through a phenotypic screening of >30 mouse lines deficient in lipid-related genes, we found that deletion of the lysophosphatidic acid (LPA) receptor LPA

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Taketomi et al. (2024) studied this question.

synapsesocial.com/papers/68e60785b6db64358759ada4 https://doi.org/10.1016/j.immuni.2024.06.012

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Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts

Abstract

Discussion

Cite This Study

Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts

Abstract

Discussion

Cite This Study

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