Figure 4 from Race-Related Differences in Sipuleucel-T Response among Men with Metastatic Castrate–Resistant Prostate Cancer

Differential cytokine and chemokine responses in AA men (n = 29) and non-AA men (n = 28). Of all Th₁ cytokines, only the baseline levels of GM-CSF were significantly higher (P = 0.001) in AA men vs. non-AA men. The levels of chemokine CCL4 (MIP-1β) were significantly higher at baseline (P = 0.0003) in AA men vs. non-AA men. The levels of CCL5 (RANTES) were significantly higher at baseline (P < 0.0001), as well as at 10 weeks post treatment (P = 0.0006) in AA men vs. non-AA men. Differences between the two racial groups were analyzed by the Mann–Whitney test and P values < 0.0032 were considered as significant in the multiple comparisons sense. The horizontal line in each dot plot marks the median value. Base, baseline; wks, weeks.