Synthesis of the 1,3-dienes from arylboronic acids with propargyl alcohols using a Ni(II) precatalysts is presented. Through detailed reaction screening NiCl2(PCy3)2 has been identified as the optimal catalyst for this transformation. The reaction is thought to proceed through a Ni(II) allenyl complex, which undergoes a base free Suzuki-Miyaura cross-coupling through arylboronic acids, with the resultant aryl allene rearranging to its 1,3-diene. Application of these optimized reaction conditions then provides several dienes in reasonable to good, isolated yields. KEY WORDS: Suzuki-Miyaura, NiCl2(PCy3)2, 1,3-Dienes, Allenyl, Base free Bull. Chem. Soc. Ethiop. 2024, 38(5), 1405-1412. DOI: https://dx.doi.org/10.4314/bcse.v38i5.16
No takes yet. Share an insight, caveat, or question.
Al-Jawaheri et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: