Long-Term Follow-Up before and during Riluzole Treatment in Six Patients from Two Families with Spinocerebellar Ataxia Type 7

Agnese Suppiej; Chiara Ceccato; Radouil Tzekov; Iveta Cermakova; Francesco Parmeggiani; Gianmarco Bellucci; Marco Salvetti; Theresa Zesiewicz; Giovanni Ristori; Silvia Romano

doi:10.1007/s12311-024-01714-w

July 8, 2024The CerebellumOpen Access

Long-Term Follow-Up before and during Riluzole Treatment in Six Patients from Two Families with Spinocerebellar Ataxia Type 7

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Key Points

Riluzole repurposing provides long-term symptomatic monitoring data for individuals diagnosed with spinocerebellar ataxia type 7, a progressive and fatal disorder.
Long-term follow-up tracking six patients across two families assesses symptom trajectories before and during riluzole treatment for rare cerebellar ataxia.
Highlights the clinical need for targeted therapeutic strategies, as no curative intervention currently exists for hereditary spinocerebellar ataxias.

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Implication

Long-term follow-up reports outcomes of riluzole treatment in spinocerebellar ataxia type 7, highlighting the potential of drug repurposing for symptomatic management.

Abstract

Currently no curative treatment exists for spinocerebellar ataxias (SCAs). Riluzole repurposing was proposed as a symptomatic treatment in different types of cerebellar ataxia. We report a long-term-follow up under riluzole treatment in SCA type 7.

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Suppiej et al. (2024) studied this question.

synapsesocial.com/papers/68e61188b6db6435875a41ec https://doi.org/10.1007/s12311-024-01714-w

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Long-Term Follow-Up before and during Riluzole Treatment in Six Patients from Two Families with Spinocerebellar Ataxia Type 7

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Long-Term Follow-Up before and during Riluzole Treatment in Six Patients from Two Families with Spinocerebellar Ataxia Type 7

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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