We obtain topological obstructions to the existence of a complete Riemannian metric with uniformly positive scalar curvature on certain (non-compact) $4$-manifolds. In particular, such a metric on the interior of a compact contractible $4$-manifold uniquely distinguishes the standard $4$-ball up to diffeomorphism among Mazur manifolds and up to homeomorphism in general. We additionally show there exist uncountably many exotic R⁴'s that do not admit such a metric and that any (non-compact) tame $4$-manifold has a smooth structure that does not admit such a metric.
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Chodosh et al. (2024) studied this question.
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